PI: Research description | Adams

Nathan Adams

Affiliation

Nanotemper Technologies GmbH
Floessergasse 4, 81369 Munich, Germany

E-Mail: nathan.adams@nanotempertech.com

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Target

At NanoTemper Technologies (NTT) we create biophysical tools for scientists to tackle their challenging characterizations. Within the High Throughput Screening Group at NTT, our goal is to use physical and software automation to increase the efficiency and subsequent throughput of our devices to help create a world where every disease is treatable. Our technologies can characterise the both the stability of a protein or biomolecule (nanoDSF, DLS, SLS), but also its binding with partners using a variety of modalities (TRIC, isothermal spectral shift, nanoDSF).

Within the NeuroTrans ETN we are using our newly develop isothermal spectral shift technology to characterise the both the equilibrium binding and thermodynamics of ligand binding to transporter proteins.

Main areas of research

•  Protein-ligand binding and stability

•  Site specific labelling and modification of proteins

•   Automation design and implementation

•   Elucidation of metabolons within metabolic pathways